PAULINE C. NG
Fred Hutchinson Cancer Research Center, 1100 Fairview Ave N, A1-162, Seattle, WA 98109 USA.
Telephone: (206) 667-4509; Fax: (206)667-5889; email: pauline@howard.fhcrc.org
/sift
Interests
Bioinformatics tool development
Database searching methods
Improved substitution scoring matrices
Consequences of nonsynonymous polymorphisms
Education
Ph.D. Bioengineering University of Washington, Seattle WA. G.P.A. 3.9 1998-present
Dissertation: “PSSMs: Not just roadkill on the information superhighway”
Advisor: Steven Henikoff, Fred Hutchinson Cancer Research Center
B.Sc. Biology Caltech,
Pasadena CA. G.P.A. 3.9 1993-1997
Ng, P.C. and Henikoff, S. (2002)
Accounting for human polymorphisms predicted to affect protein function. Genome Research, in press.
Ng P.C. and Henikoff, S. (2001)
Predicting deleterious amino acid substitutions. Genome Research. 11:863-74.
Ng P.C., Henikoff J.G., and Henikoff, S. (2000) PHAT: a transmembrane-specific substitution matrix. Bioinformatics 16: 760-6.
Awards
Department of Energy Computational Science Graduate Fellowship 2000-present
Awarded to twenty graduate students in the United States.
National Science Foundation Fellowship 1998-2000
Scholarship winner, Keystone Symposia: Human Genetics and Genomics 2001
Tau Beta Pi Engineering Honor Society
Sigma Xi Research Society
Additional experience
Department of Energy practicum 2001
Dr. Natalia Maltsev, Math and Computer Science Division, Argonne National Laboratory
Cross-species comparison of the evolution of proteins in the purine and pyrimidine pathway.
Imaging Researcher 1997-1998
Prof. Scott Fraser, Biological Imaging Center, Caltech
Characterized novel two-photon dyes in living systems using two-photon and confocal
microscopy.
Abstracts presented at
national meetings
Ng, P.C. and Henikoff, S. SIFTing the human genome for damaging polymorphisms. Poster to be presented at HUGO Human Genome Meeting, Shanghai, China (upcoming in 2002).
Ng, P.C. and Henikoff, S. SIFT: A sequence-based tool for predicting deleterious amino acid substitutions. Poster presented at Keystone Symposia: Human Genetics and Genomics, Breckenridge CO (2001).
Ng, P.C., Henikoff, J.G., and Henikoff, S. PHAT: A transmembrane-specific substitution matrix. Poster presented at Intelligent Systems for Molecular Biology, U.C. San Diego (2000).
Teaching experience
Lecturer, Genotype to Phenotype workshop, Fred Hutchinson Cancer Research Center 2001
Educational Outreach Intern, Chevron, Richmond, CA. 1998
Designed laboratory setups and information sessions for high school students in the Chemathon,
an annual chemistry competition. Prepared lecture notes, tests, and slides.
Teaching Assistant, Undergraduate Biology Course, California Institute of Technology 1996
References
Steven Henikoff (advisor), Principal Investigator, Dept. of Basic Sciences, Fred Hutchinson Cancer Research Center. steveh@muller.fhcrc.org
Natalia Maltsev, Principal Investigator, Div. of Mathematics and Computer Science, Argonne National Laboratory. maltsev@mcs.anl.gov
Philip Green, Professor, Dept. of Genome Sciences, University of Washington. phg@u.washington.edu
Cornelia Ulrich, Assistant Professor, Dept. of Public Health Sciences, Fred Hutchinson Cancer Research Center. nulrich@fhcrc.org