PAULINE C. NG


Fred Hutchinson Cancer Research Center, 1100 Fairview Ave N, A1-162, Seattle, WA 98109 USA.

Telephone: (206) 667-4509; Fax: (206)667-5889; email: pauline@howard.fhcrc.org

/sift


Interests

 

Bioinformatics tool development

    Database searching methods

    Improved substitution scoring matrices

Consequences of nonsynonymous polymorphisms

 


Education

 

Ph.D. Bioengineering       University of Washington, Seattle WA. G.P.A. 3.9               1998-present

Dissertation: “PSSMs: Not just roadkill on the information superhighway”

Advisor: Steven Henikoff, Fred Hutchinson Cancer Research Center    

 

B.Sc. Biology                Caltech, Pasadena CA. G.P.A. 3.9                                     1993-1997

 


Publications

 

Ng, P.C. and Henikoff, S. (2002) Accounting for human polymorphisms predicted to affect protein function.  Genome Research, in press.

 

Ng P.C. and Henikoff, S. (2001) Predicting deleterious amino acid substitutions. Genome Research. 11:863-74.

 

Ng P.C., Henikoff J.G., and Henikoff, S. (2000) PHAT: a transmembrane-specific substitution matrix.  Bioinformatics 16: 760-6.

 


Awards

 

Department of Energy Computational Science Graduate Fellowship                              2000-present

Awarded to twenty graduate students in the United States. 

 

National Science Foundation Fellowship                                                                 1998-2000

 

Scholarship winner, Keystone Symposia: Human Genetics and Genomics                      2001

 

Tau Beta Pi Engineering Honor Society

 

Sigma Xi Research Society

 


Additional experience

 

Department of Energy practicum                                                                             2001

Dr. Natalia Maltsev, Math and Computer Science Division, Argonne National Laboratory

Cross-species comparison of the evolution of proteins in the purine and pyrimidine pathway.

 

Imaging Researcher                                                                                              1997-1998

            Prof. Scott Fraser, Biological Imaging Center, Caltech

            Characterized novel two-photon dyes in living systems using two-photon and confocal

microscopy. 

[P1] 


Abstracts presented at national meetings

 

Ng, P.C. and Henikoff, S. SIFTing the human genome for damaging polymorphisms.  Poster to be presented at HUGO Human Genome Meeting, Shanghai, China (upcoming in 2002).

 

Ng, P.C. and Henikoff, S.  SIFT: A sequence-based tool for predicting deleterious amino acid substitutions.  Poster presented at Keystone Symposia: Human Genetics and Genomics, Breckenridge CO (2001). 

 

Ng, P.C., Henikoff, J.G., and Henikoff, S.  PHAT: A transmembrane-specific substitution matrix.  Poster presented at Intelligent Systems for Molecular Biology, U.C. San Diego (2000).

 


Teaching experience

 

Lecturer, Genotype to Phenotype workshop, Fred Hutchinson Cancer Research Center     2001

 

Educational Outreach Intern, Chevron, Richmond, CA.                                              1998

Designed laboratory setups and information sessions for high school students in the Chemathon,

an annual chemistry competition.  Prepared lecture notes, tests, and slides.

 

Teaching Assistant, Undergraduate Biology Course, California Institute of Technology    1996

                       


References

 

Steven Henikoff (advisor), Principal Investigator, Dept. of Basic Sciences, Fred Hutchinson Cancer Research Center.  steveh@muller.fhcrc.org

 

Natalia Maltsev, Principal Investigator, Div. of Mathematics and Computer Science, Argonne National Laboratory.  maltsev@mcs.anl.gov

 

Philip Green, Professor, Dept. of Genome Sciences, University of Washington. phg@u.washington.edu

 

Cornelia Ulrich, Assistant Professor, Dept. of Public Health Sciences, Fred Hutchinson Cancer Research Center.  nulrich@fhcrc.org

           

 


 [P1]